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Research in the Biscoe group:

Research in the Biscoe lab involves the study of fundamental organometallic reactivity and mechanism, and the application of these studies to the development of new synthetic strategies for the generation of biologically active organic molecules. Specifically, we seek to develop new synthetic approaches that enable the rational and reliable manipulation of molecules in three dimensions. In this work, we employ configurationally stable, enantioenriched organometallic nucleophiles as a source of stereogenic carbon centers that can be transferred and manipulated via stereospecific cross-coupling reactions. Currently, transition metal-catalyzed cross-coupling methodologies can be reliably used for the preparation of flat, conjugated molecular subunits, but not for branched (chiral) molecular topologies. Consequently, the development of cross-coupling methods that enable the stereospecific transfer of a stereogenic center would constitute a new approach to asymmetric synthesis. Our strategies towards the predictable modification of three-dimensional molecular structure are currently being implemented in medicinal chemistry, as well as in material science.