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Michael Sattler, Professor and Chair, Biomolecular NMR Spectroscopy, Department of Bioscience, Technical University of Munich, Garching, Munchen, Germany, will give a talk titled, "NMR in 4D integrative structural biology - from dynamics and mechanisms to novel therapeutics."

This seminar will also be available by Zoom. Zoom link: ; Meeting ID 921 2527 1835.  Passcode: sbiandccny

Please note: 

* Full names must be used to be admitted to the Zoom meeting.

* The Zoom meeting will be closed and locked at 12:15 p.m., and no one will be able to enter the meeting after that time.

ABSTRACT

We employ integrative structural biology, combining solution NMR with complementary techniques and molecular dynamics to study the dynamics of RNAs and RNA-protein interactions in RNA processing pathways, including alternative splicing regulation and non- coding RNA pathways. The structural understanding is a starting point to identify small molecule inhibitors that modulate these pathways for novel therapeutic approaches. Starting from a brief outline of our work and approaches in splicing regulation, two studies will be presented: (1) We discovered extensive dynamics associated with A-to-I hyper-edited dsRNAs, which exhibit unique conformational features. These features are specifically associated with hyper-editing and are specifically recognized by inosine binding proteins such as Endonuclease V. (2) We are dissecting the molecular principles of biomolecular condensates that are implicated in the separation of small non-coding RNA pathways in Drososphila, combining NMR, biophysical techniques and cell microscopy.